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MedChemExpress LLC
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Chemokine Receptor (趋化因子受体)蛋白
MCE 国际站:Chemokine Receptor
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文献和实验趋化因子及其受体 趋化因子(chemokine)是一组小分子质量(8―1lkDa)蛋白的集合,是细胞因子家族中惟一作用于G蛋白偶联受体超家族的成员。它们直接参与白细胞特别是吞噬细胞和淋巴细胞的游走和活化,参与炎症反应并在其中起核心作用。趋化因子还具有其他多效性功能,如对肿瘤生长的调节,参与免疫系统、循环系统和神经系统的发育等。 迄今发现的人的趋化因子约有50种。趋化因子的序列相似性较低,但是三维空间结构存在显著的同源性。它们都是单链蛋白,拥有相同的单体蛋白
Detailed understanding of chemokine action ultimately requires molecular cloning of chemokine receptor genes and cDNAs. Both forward and reverse genetic methods have been used for this purpose (1 ). Forward methods, which involve primary
Epigenetic Regulation of Chemokine/Chemokine Receptor Expression
for several members of the CXC (ELR+ ) chemokine family. In addition we describe a chromatin immunoprecipitation assay to determine the association between chromatin transcription markers and DNA following pretreatment of cell cultures with an HDi, Trichostatin A (TSA
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