HSP40

Peptide substrate identification for yeast Hsp40 Ydj1 by screening the phage display library

We have identified a peptide substrate for molecular chaperone Hsp40 Ydj1 by utilizing the combination of phage display library screening and isothemol titration calirimetry (ITC). The initial peptide substrate screening for Hsp40 Ydj

Reconstitution of CHIP E3 Ubiquitin Ligase Activity

chaperone activity to either deliver the substrate to CHIP or to maintain the substrate in a ubiquitination-competent conformation. This chaperone activity can be provided by the Hsp70/Hsp40 molecular chaperone system as seen in the NBD1–R ubiquitination

The Role of p23, Hop, Immunophilins, and Other Co-chaperones in Regulating Hsp90 Function

, such as Hsp70s and Hsp40s, recognize and transiently bind polypeptides with exposed hydrophobic stretches in order to prevent misfolding. Other types of chaperones, such as Hsp90, have more specialized functions in that they appear to interact