Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
英文名:
Human CD150 Protein, His Tag
库存:
999
供应商:
卡梅德生物科技(天津)有限公司
规格:
10ug/50ug
规格:
10ug
产品价格:
¥896.0
规格:
50ug
产品价格:
¥2688.0
产品编号: KMP2358产品名称: Human CD150 Protein, His Tag中文名称: 重组人CD150蛋白中文全称: 重组人信号淋巴细胞激活分子家族成员 1蛋白关键词: 信号淋巴细胞激活分子家族成员 1, Signaling Lymphocytic Activation Molecule, CDw150, IPO-3, CD150, SLAMF1, SLAM, Human CD150 Protein, His Tag, Recombinant Protein, KMP2358物种: Human宿主: HEK293 Cells规格: 50ug, 100ug, 200ug纯化方式: Affinity purification纯度: >95% as determined by SDS-PAGE内毒素水平: <1.0 EU/ug determined by the LAL method缓冲体系: 20mM PB, 150mM NaCl, pH7.4Uniprot: Q13291SDS-PAGE: KMP2358 SDS-PAGE image1.png功能: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including SHIP1 and PTPN11/SHP-2.However, signaling is also regulated by SH2D1A which can simultaneously interact with and recruit FYN which subsequently phosphorylates and activates SLAMF1.Mediates IL-2-independent proliferation of activated T-cells during immune responses and induces IFN-gamma production (By similarity).Downstreaming signaling involves SHIP1, DOK1 and DOK2 leading to inhibited IFN-gamma production in T-cells, and PRKCQ, BCL10 and NFKB1 leading to increased T-cell activation and Th2 cytokine production (By similarity).Promotes T-cell receptor-induced IL-4 secretion by CD4+ cells (By similarity).Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4-/CD8- T-cells (By similarity).Required for IL-4 production by germinal centers T follicular helper (T(Fh))cells (By similarity).May inhibit CD40-induced signal transduction in monocyte-derived dendritic cells.May play a role in allergic responses and may regulate allergen-induced Th2 cytokine and Th1 cytokine secretion (By similarity).In conjunction with SLAMF6 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage. Involved in the peripheral differentiation of indifferent natural killer T (iNKT) cells toward a regulatory NKT2 type (By similarity).In macrophages involved in down-regulation of IL-12, TNF-alpha and nitric oxide in response to lipopolysaccharide (LPS) (By similarity).In B-cells activates the ERK signaling pathway independently of SH2D1A but implicating both, SYK and SHIP1, and activates Akt signaling dependent on SYK and SH2D1A (By similarity).In B-cells also activates p38 MAPK and JNK1 and JNK2.In conjunction with CD84/SLAMF5 and SLAMF6 may be a negative regulator of the humoral immune response (By similarity).Involved in innate immune response against Gram-negative bacteria in macrophages; probably recognizes OmpC and/or OmpF on the bacterial surface, regulates phagosome maturation and recruitment of the PI3K complex II (PI3KC3-C2) leading to accumulation of PdtIns3P and NOX2 activity in the phagosomes.(Microbial infection) Acts as a receptor for Measles virus; also including isoform 4.产品背景: SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C(PTPN11)-dependent signal transduction operates.保存条件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.运输条件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.说明: This product is for research use only.官网链接: https://www.kmdbioscience.cn/参考文献: 1.Blood 107:2821-2829 (2006) 2.Immunol. Cell Biol. 88:565-574 (2010) 3.Nat. Immunol. 11:920-927 (2010) 4.Blood 99:957-965 (2002) 5.J. Biol. Chem. 278:3852-3859 (2003) 6.Nature 406:893-897 (2000) 7.PLoS ONE 10:E0118302-E0118302 (2015)