Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
英文名:
Human CD274 Protein, Flag Tag
库存:
999
供应商:
卡梅德生物科技(天津)有限公司
规格:
10ug/50ug
规格:
10ug
产品价格:
¥832.0
规格:
50ug
产品价格:
¥1920.0
产品编号: KMP2355产品名称: Human CD274 Protein, Flag Tag中文名称: 重组人CD274蛋白中文全称: 重组人程序性死亡蛋白配体-1蛋白关键词: 程序性死亡蛋白配体-1, B7-H, B7H1, B7-H1, B7H1PDCD1L1, CD274 antigenMGC142294, CD274 molecule, CD274, PDCD1L1, PDCD1LG1, PDL1, PD-L1, PD-L1B7 homolog 1, PDL1PDCD1 ligand 1, programmed cell death 1 ligand 1, Programmed death ligand 1, Human CD274 Protein, Flag Tag, Recombinant Protein, KMP2355物种: Human宿主: HEK293 Cells规格: 50ug, 100ug, 200ug纯化方式: Affinity purification纯度: >95% as determined by SDS-PAGE内毒素水平: <1.0 EU/ug determined by the LAL method缓冲体系: 20mM PB, 150mM NaCl, pH7.4Uniprot: Q15116SDS-PAGE: KMP2355 SDS-PAGE image1.png功能: Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self.Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 .Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation.Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta.The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival .The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function .The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy .产品背景: CD274, also known as B7-H1 or programmed death ligand 1(PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1(PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.保存条件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.运输条件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.说明: This product is for research use only.官网链接: https://www.kmdbioscience.cn/参考文献: 1.Ann. N. Y. Acad. Sci. 1217:45-59 (2011)2.Gene 638:20-25 (2018)