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- 保存条件:
Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
- 英文名:
Human CD137L Protein, His Tag
- 库存:
999
- 供应商:
卡梅德生物科技(天津)有限公司
- 规格:
10ug/50ug
| 规格: | 10ug | 产品价格: | ¥1344.0 |
|---|---|---|---|
| 规格: | 50ug | 产品价格: | ¥4032.0 |
产品编号:KMP2413
产品名称:Human CD137L Protein, His Tag
中文名称: 重组人CD137L蛋白
中文全称:重组人肿瘤坏死因子配体超家族成员9蛋白
产品描述:The Human CD137L Protein(KMP2413) is produced in E.coli and the target gene encoding Arg71-Glu254 is expressed with a 6His tag at the C-terminus.
产品别称:肿瘤坏死因子配体超家族成员 9, CD137L, TNFSF9
分子名称:CD137L
预测分子量:20.9 kDa
物种:Human
宿主:E. coli
规格:50ug, 100ug, 200ug
纯化方式:Affinity purification
纯度:>95% as determined by SDS-PAGE
内毒素水平:<1.0 EU/ug determined by the LAL method
缓冲体系:20mM TrisHCl, 150mM NaCl, pH7.4
Uniport:P41273
功能:Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
产品背景:Tumor necrosis factor ligand superfamily member 9(4-1BBL) is single-pass type II membrane protein which is a member of the the tumor necrosis factor family. 4-1BBL is a 254 amino acids cytokine that is expressed in brain, placenta, lung, skeletal muscle and kidney. TNFSF9 has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine may have a role in activation-induced cell death(AICD) and cognate interactions between T-cells and B-cells/macrophages. It has also been shown to be required for the optimal CD8 responses in CD8 T cells, and is thought to be involved in T cell-tumor cell interaction.
保存条件:Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
运输条件:In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
说明:This product is for research use only.
参考文献:J. Biol. Chem. 285:9202-9210 (2010)
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文献和实验IJMS:利用转基因水稻种子表达功能性重组人碱性成纤维细胞生长因子
Journal of Molecular Sciences》。 该研究表明通过转基因水稻产生的重组人碱性成纤维细胞生长因子与商业化的重组人碱性成纤维细胞生长因子的功能活性基本一致,例如在促进NIH/3T3细胞增殖以及体外伤口愈合治疗中的活性一致。这项研究再次证明了利用水稻胚乳体系表达各种生物医药蛋白是非常有前景的。 碱性成纤维细胞生长因子(FGF-2)是成纤维细胞生长因子家族中非常重要的成员。由于碱性成纤维细胞生长因子能促进细胞的增殖,其在临床中的烧伤和伤口的愈合治疗中有着非常广泛
个β亚单位通过链间二硫键形成的异源四聚体。其中α亚单位为配体结合部位;β亚单位的胞浆内部分含有酪氨酸激酶活性区域。 (3)PDGF/MCSF/SCF受体家族:其家族成员包括血小板衍生的生长因子α受体(PDGF-αR)、PDGF-βR、巨噬细胞集落刺激因子受体(M-CSFR)以及干细胞生长因子受体(SCFR)。以上成员的特点是胞膜外含有5个免疫球蛋白样结构域,胞浆内含有两个呈串联结构的酪酸激酶功能区。 (4)成纤维细胞生长因子受体(FGFR)家族:FGFR家族成员有FGFR
。如免疫球蛋白超家族(1gSF)成员。 Ⅱ型:一次跨膜,多肽链的C端在胞膜外,N端在胞内。如肿瘤坏死因子超家族成员的分子。 Ⅲ型:一条多肽链多次跨膜,跨膜次数有二、三、四、五、六或七次等,其中四次跨膜超家族(TM4―SF)和七次跨膜受体超家族(STR-SF)分子较为常见。如趋化因子受体均属STM-SF,又称G蛋白偶联受体(Gprotein-coupledreceptor)。 Ⅳ型:由多个跨膜亚单位组成。 V型:多肽链以糖基磷脂酰肌醇
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