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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
- 英文名:
Mouse Gi24 Protein, His Tag
- 库存:
999
- 供应商:
卡梅德生物科技(天津)有限公司
- 规格:
10ug/50ug
| 规格: | 10ug | 产品价格: | ¥1216.0 |
|---|---|---|---|
| 规格: | 50ug | 产品价格: | ¥3200.0 |
产品编号:KMP2323
产品名称:Mouse Gi24 Protein, His Tag
中文名称: 重组鼠Gi24蛋白
中文全称:重组鼠V集免疫调节受体蛋白
产品描述:产品描述:The Mouse Gi24 Protein(KMP2323) is produced in HEK293 Cells and the target gene encoding Phe33-Ala191 is expressed with a 6His tag at the C-terminus.
产品别称:V 集免疫调节受体, Platelet receptor Gi24, Gi24
分子名称:Gi24
预测分子量:18.96 kDa
物种:Mouse
宿主:HEK293 Cells
规格:50ug, 100ug, 200ug
纯化方式:Affinity purification
纯度:>95% as determined by SDS-PAGE
内毒素水平:<1.0 EU/ug determined by the LAL method
缓冲体系:PBS, pH7.4
Uniport:Q9D659
功能:Immunoregulatory receptor which inhibits the T-cell response (PubMed:21383057, PubMed:24743150, PubMed:25267631). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (PubMed:20042595). May stimulate MMP14-mediated MMP2 activation (By similarity).
产品背景:Mouse Platelet receptor Gi24(VISTA) is a transmembrane glycoprotein with homology to B7like immune costimulatory molecules. Mature mouse Gi24 contains a 159 amino acid(aa) extracellular domain(ECD) with one V-type Ig-like domain, a 21 aa transmembrane segment, and a 97 aa cytoplasmic domain. VISTA promotes both MT1-MMP expression and the MT1-MMP mediated activation of MMP-2. It supports the differentiation of embryonic stem cells(ESC) and enhances BMP-4 induced signaling in ESC, but it is also down-regulated following BMP-4 exposure. It binds to BMP-4 directly and also associates with the type I BMP receptor Activin RIB/ALK-4. It is expressed on the surface of na-ve CD4+ T cells and regulatory T cells. It is up-regulated in vivo on activated monocytes and dendritic cells. VISTA inhibits CD4+ and CD8+ T cell proliferation and their production of IL-2 and IFN-γ. Its expression on tumor cells attenuates the antitumor immune response and enables more rapid tumor progression.
保存条件:Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
运输条件:In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
说明:This product is for research use only.
参考文献:1.J. Biol. Chem. 285:7776-7783 (2010) 2.J. Exp. Med. 208:577-592 (2011) 3.J. Clin. Invest. 124:1966-1975 (2014) 4.Proc. Natl. Acad. Sci. U.S.A. 111:14846-14851 (2014)
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