- ￥1216 - 3200
- 卡梅德/KMD Bioscience
- 天津
- KMP2322
- 2025年10月14日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
- 英文名：
Mouse CD226 Protein, His Tag
- 库存：
999
- 供应商：
卡梅德生物科技（天津）有限公司
- 规格：
10ug/50ug
| 规格： | 10ug | 产品价格： | ￥1216.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥3200.0 |
产品编号：KMP2322
产品名称：Mouse CD226 Protein, His Tag
中文名称： 重组鼠CD226蛋白
中文全称：重组鼠白细胞分化抗原蛋白
产品描述：产品描述：The Mouse CD226 Protein(KMP2322) is produced in HEK293 Cells and the target gene encoding Glu19-Pro254 is expressed with a 6His tag at the C-terminus.
产品别称：白细胞分化抗原, CD226 antigen, CD226
分子名称：CD226
预测分子量：27.61 kDa
物种：Mouse
宿主：HEK293 Cells
规格：50ug, 100ug, 200ug
纯化方式：Affinity purification
纯度：>95% as determined by SDS-PAGE
内毒素水平：<1.0 EU/ug determined by the LAL method
缓冲体系：PBS, pH7.4
Uniport:Q8K4F0
功能：Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding.
产品背景：Mouse DNAX accessory molecule-1(DNAM-1) is a type I transmembrane glycoprotein that belongs to the immunoglobulin superfamily. As an activating receptor, it interacts with the ligands CD155 and CD112, and activates natural killer(NK) cells via its immu-noreceptor tyrosine-based activatory motif(ITAM). Mature mouse DNAM-1 has extracellular domain(ECD) that contains two Ig-like C2-set domains, and possesses a cytoplasmic region that contains motifs for binding PDZ domains. DNAM-1 is expressed on several lymphoid and myeloid cell types and interacts with CD155/PVR and Nectin-2/CD112. Ligation of DNAM-1 promotes the activation of NK cells, CD8+ T cells, and mast cells, induces dendritic cell maturation, initiates megakaryocyte and activated platelet adhesion to vascular endothelial cells, and stimulates monocyte extravasation- Conversely, it inhibits the formation of osteoclasts. Platelet-endothelium interactions that are mediated by DNAM-1 enable the metastasis of tumor cells to the lung.
保存条件：Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
运输条件：In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
说明：This product is for research use only.
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文献和实验基因免疫技术（Gene immunization technique）
一、 概 述 (一) 基因免疫的概念 基因免疫(gene immunization)又称DNA免疫或核酸免疫，是指将编码某种抗原蛋白的外源基因(DNA或RNA) 与质粒重组后,利用某种方法直接导入动物细胞内,使带有目的基因的表达载体转化到体内,通过宿主细胞的转录系统合成抗原蛋白,诱导宿主产生针对该抗原蛋白的抗体并引起特异的免疫应答以达到预防和治疗的目的,因此也将这种免疫制剂称为基因疫苗(gene vaccine)或核酸
重组 人类白细胞介素-4的晶体结构 白细胞介素-4(白介素-4, Interleukin-4, IL-4)是II型辅助T细胞(Th2细胞)分泌的细胞因子。白细胞介素-4的生物作用，包括刺激活化B细胞和T细胞增殖、 CD4+T细胞分化成II型辅助T细胞. 它也在调节体液免疫 和适应性免疫中起关键作用。白细胞介素-4诱导B细胞抗体类别转换向IgE，上调第二型主要组织兼容性复合体的产生。这一因子是由M.霍华德、W.保罗和E. 委特塔(Vitetta)在1982共同
网络 二、集落刺激因子（CSF) 骨髓造血干细胞体外半固体培养技术的建立和重组集落刺激因子（colony-stimulating factor,CSF)的问世给集落刺激因子的研究提供了前提。根据细胞因子刺激不同造血细胞系或不同分化阶段的细胞在半固体培养基中形成不同细胞集落，分别命名为粒细胞CSF（G-CSF）、巨噬细胞CSF（M-CSF）、粒细胞和巨噬
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