重组鼠CD278蛋白|重组鼠诱导性 T 细胞成本刺激器蛋白

产品编号：KMP2314

产品名称：Mouse CD278 Protein, His Tag

中文名称： 重组鼠CD278蛋白

中文全称：重组鼠诱导性T细胞成本刺激器蛋白

产品描述：产品描述：The Mouse CD278 Protein(KMP2314) is produced in HEK293 Cells and the target gene encoding Glu21-Leu142 is expressed with a 6His tag at the C-terminus.

产品别称：诱导性 T 细胞成本刺激器, Inducible T-cell costimulator, CD278

分子名称：CD278

预测分子量：14.72 kDa

物种：Mouse

宿主：HEK293 Cells

规格：50ug, 100ug, 200ug

纯化方式：Affinity purification

纯度：>95% as determined by SDS-PAGE

内毒素水平：<1.0 EU/ug determined by the LAL method

缓冲体系：PBS, pH7.4

Uniport:Q9WVS0#function

功能：Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.

产品背景：Inducible Costimulator(ICOS) is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA4 and PD1. ICOS shares approximately 39% amino acid similarity with CD 28 and CTLA4. Mouse and human ICOS share approximately 72% amino acid identity. ICOS is expressed on most CD45RO+ cells. ICOS expression is up-regulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation. In addition, ICOS is more potent in the induction of IL-10 production, acytokine important for suppressive function of T regulatory cells.

保存条件：Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.

运输条件：In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.

说明：This product is for research use only.

参考文献：1.Nature 402:827-832 (1999) 2.Nature 409:102-105 (2001) 3.Nature 409:105-109 (2001)