重组鼠CD152蛋白|重组鼠细胞毒T淋巴细胞相关抗原蛋白

产品编号：KMP2312

产品名称：Mouse CD152 Protein, Flag Tag

中文名称： 重组鼠CD152蛋白

中文全称：重组鼠细胞毒T淋巴细胞相关抗原蛋白

产品描述：产品描述：The Mouse CD152 Protein(KMP2312) is produced in HEK293 Cells and the target gene encoding Ala37-Asp161 is expressed with a Flag tag at the C-terminus.

产品别称：细胞毒T淋巴细胞相关抗原, Cytotoxic T-lymphocyte protein 4, CD152

分子名称：CD152

预测分子量：14.73 kDa

物种：Mouse

宿主：HEK293 Cells

规格：50ug, 100ug, 200ug

纯化方式：Affinity purification

纯度：>95% as determined by SDS-PAGE

内毒素水平：<1.0 EU/ug determined by the LAL method

缓冲体系：PBS, pH7.4

Uniport:Q7TMX1

功能：Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.

产品背景：Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. Within the ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found inregulatory T cells and may play an important role in their functions. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA4. Genetic variations of CTLA4 have been associated with susceptibility to systemic lupus erythematosus(SLE), Gravesdisease(GRD), Celiac disease type3(CELIAC3) and Hepatitis B virus infection(HBVinfection).

保存条件：Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.

运输条件：In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.

说明：This product is for research use only.