Cynomolgus HAVCR2重组蛋白|食蟹猴甲型肝炎病

产品编号：KMP2310

产品名称：Cynomolgus HAVCR2 Protein, Fc Tag

中文名称： Cynomolgus HAVCR2重组蛋白

中文全称：食蟹猴甲型肝炎病毒细胞受体2重组蛋白

产品描述：产品描述：The Cynomolgus HAVCR2 Protein(KMP2310) is produced in HEK293 Cells and the target gene encoding Ser22-Arg201 is expressed with a Fc tag at the C-terminus.

产品别称：甲型肝炎病毒细胞受体 2, Hepatitis A virus cellular receptor 2, HAVCR2

分子名称：HAVCR2

预测分子量：19.8 kDa

物种：Cynomolgus

宿主：HEK293 Cells

规格：50ug, 100ug, 200ug

纯化方式：Affinity purification

纯度：>95% as determined by SDS-PAGE

内毒素水平：<1.0 EU/ug determined by the LAL method

缓冲体系：PBS, pH7.4

Uniport:G7P6Q7

产品背景：T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid(aa)extracellular domain(ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells(macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells(Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. TIM3 interactions with Galectin-9 can trigger immune stimulatory effects, such as the coactivation of NK cell cytotoxicity.

保存条件：Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.

运输条件：In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.

说明：This product is for research use only.