Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
英文名:
Human CD223 Protein, mFc Tag
库存:
999
供应商:
卡梅德生物科技(天津)有限公司
规格:
10ug/50ug
规格:
10ug
产品价格:
¥960.0
规格:
50ug
产品价格:
¥2688.0
产品编号: KMP2285产品名称: Human CD223 Protein, mFc Tag中文名称: 重组人 LAG3/CD223蛋白中文全称: 重组人CD223/淋巴细胞活化基因3蛋白关键词: 淋巴细胞激活基因-3, Lymphocyte activation gene 3 protein, LAG3, LAG-3, Protein FDC, CD223, Human CD223 Protein, mFc Tag, Recombinant Protein, KMP2285物种: Human宿主: HEK293 Cells规格: 50ug, 100ug, 200ug纯化方式: Affinity purification纯度: >95% as determined by SDS-PAGE内毒素水平: <1.0 EU/ug determined by the LAL method缓冲体系: PBS, pH7.4Uniprot: Q08830SDS-PAGE: KMP2285 SDS-PAGE image1.png功能: Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 (PubMed:30580966).Responsible for LAG3 T-cell inhibitory function (PubMed:30580966).Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966).Secreted by, and promotes growth of, hepatocytes (PubMed:11470158, PubMed:19880967).产品背景: Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin(Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.保存条件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.运输条件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.说明: This product is for research use only.官网链接: https://www.kmdbioscience.cn/参考文献: 1.Biochim. Biophys. Acta 1520:45-53 (2001) 2.Gut 59:817-826 (2010) 3.Cell 0:0-0 (2018)