Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
英文名:
Human CD28 Protein, His Tag
库存:
999
供应商:
卡梅德生物科技(天津)有限公司
规格:
10ug/50ug
规格:
10ug
产品价格:
¥912.0
规格:
50ug
产品价格:
¥2720.0
产品编号: KMP2267产品名称: Human CD28 Protein, His Tag中文名称: 重组人CD28蛋白中文全称: 重组人T细胞特异性表面糖蛋白CD28蛋白关键词: T细胞特异性表面糖蛋白CD28, CD28, CD28 molecule, Tp44, MGC138290, CD28 antigen, CD28 antigen(Tp44), T-cell-specific surface glycoprotein, Human CD28 Protein, His Tag, Recombinant Protein, KMP2267物种: Human宿主: HEK293 Cells规格: 50ug, 100ug, 200ug纯化方式: Affinity purification纯度: >95% as determined by SDS-PAGE内毒素水平: <1.0 EU/ug determined by the LAL method缓冲体系: 20mM Tris, 150mM NaCl, pH8.0Uniprot: Q96BF3SDS-PAGE: 功能: Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.产品背景: T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type(immunoglobulin-like) domain. It belongs to the immunoglobulin(Ig) superfamily. CD28 is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation.CD28 co-stimulation is necessary for CD4 positive T-cell proliferation and survival, interleukin-2 production, and T-helper type-2 development. Human post-thymic regulatory T cells require CD28 co-stimulation to expand and maintain potent suppressive function in vivo. Apoptosis plays a key role in the age-related decline of CD28 expression and in immunosenescence. CD28 is the receptor for CD80(B7.1) and CD86(B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells(APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.保存条件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.运输条件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.说明: This product is for research use only.官网链接: https://www.kmdbioscience.cn/参考文献: 1.Mol. Biol. Cell 23:1646-1656 (2012)2.Nat. Commun. 4:2043-2043 (2013)