重组人5T4蛋白|5T4蛋白|重组人滋养层糖蛋白

产品编号：KMP2244

产品名称：Human 5T4 Protein, Avi Tag, His Tag

中文名称： 重组人5T4蛋白

中文全称：重组人滋养层糖蛋白

产品描述：产品描述：The Human 5T4 Protein(KMP2244) is produced in HEK293 Cells and the target gene encoding Ser32-Ser355 is expressed with a AVI, 6His tag at the C-terminus.

产品别称：滋养层糖蛋白, Human M6P1 Protein, 5T4

分子名称：5T4

预测分子量：36.15 kDa

物种：Human

宿主：HEK293 Cells

规格：50ug, 100ug, 200ug

纯化方式：Affinity purification

纯度：>95% as determined by SDS-PAGE

内毒素水平：<1.0 EU/ug determined by the LAL method

缓冲体系：PBS, pH7.4

Uniport:Q13641#structure

功能：May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.

产品背景：Trophoblast glycoprotein, also known as TPBG and 5T4, it belongs to the LRR family of proteins. The C-terminus of LRR N-terminal cap(LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway. TPBG may function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. It expressed by all types of trophoblasts as early as 9 weeks of development. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.

保存条件：Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.

运输条件：In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.

说明：This product is for research use only.

参考文献：1 Dev. Cell 21:1129-1143 (2011)