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- 详细信息
- 文献和实验
- 技术资料
- 抗体名:
EpCAM Antibody 抗体
- 抗体英文名:
EpCAM Antibody
- 浓度:
详询
- 应用范围:
FACS, IHC-P
- 宿主:
Mouse
- 适应物种:
Human
- 保质期:
6-12个月
- 抗原来源:
详询
- 目录编号:
orb1716206
- 级别:
科研
- 库存:
99
- 供应商:
Biorbyt
- 标记物:
Unconjugated
- 克隆性:
RECOMBINANT
- 保存条件:
Aliquot the recombinant EpCAM antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
- 形态:
详询
- 亚型:
Mouse IgG1, kappa
- 免疫原:
Recombinant full-length human protein was used as the immunogen for the recombinant EpCAM antibody.
- 规格:
20 ug
EGP40 is a 40-43kDa transmembrane epithelial glycoprotein, also identified as epithelial specific antigen (ESA), or epithelial cellular adhesion molecule (Ep-CAM). It is expressed on baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas. This antibody has been used to distinguish adenocarcinoma from pleural mesothelioma and hepatocellular carcinoma. This antibody is also useful in distinguishing serous carcinomas of the ovary from mesothelioma.
产品名:EpCAM Antibody
货号:orb1716206
产品中文名:EpCAM Antibody 抗体
产品详情链接:https://www.biorbyt.com/epcam-antibody-orb1716206.html
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文献和实验STM:广州医科大学刘铭/谢茂彬合作发现肝细胞癌的新潜在治疗靶点 Claudin 6
显示,CLDN6 可以稳定 YAP1,促进其核转位,从而活化 Hippo 通路。 IP 结果显示 CLDN6 与 YAP1 竞争性结合 TJP2 鉴于 CLDN6 是多次跨膜蛋白,但其不具有(或尚未发现?)配体结合结构域,难以设计小分子药物;而如果使用单抗的话,由于肝细胞癌具有复杂的微环境, T 细胞难以发挥足够的抗体依赖细胞毒性(ADCC)效应杀伤癌细胞。因此,作者设计了靶向 CLDN6 的抗体偶联药物(Antibody-Drug Conjugate, ADC),将细胞毒性药物 DM1 和 CLDN6 抗体
grafts from the same patient (graft). Stains shown are hematoxylin and eosin (H&E) as well as antibody stains for ER, PR, HER2, cytokeratin (CK), E‐cadherin (E‐cad), β‐catenin (β‐cat), and human‐specific vimentin (hVim). Positive antibody signals
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