BioGems Nicotinamide（50mg）

Catalog Number : 9899208
descriptionNicotinamide is an amide of nicotinic acid, a vitamin of the B complex. In cells, it is incorporated into NADP+ and NAD+, coenzymes for a wide variety of enzymatic oxidation-reduction reactions. Nicotinamide is reported to exhibit anti-inflammatory properties and promote the differentiation of mesenchymal stem cells to insulin producing cells in conjunction with growth factors and other reagents. Nicotinamide suppresses sirtuin activity and is used to promote the formation and increase the lifespan of organoids.

Molecular Formula:
C6H6N2O

Molecular Weight:
122.1
CAS Number
98-92-0
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:
Bartfeld, S., Bayram, T., van de Wetering, M., Huch, M., Begthel, H., Kujala, P., ... & Clevers, H. (2015). In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology, 148(1), 126-136.

Revollo, J. R., Grimm, A. A., & Imai, S. I. (2004). The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. Journal of Biological Chemistry, 279(49), 50754-50763.

Busso, N., Karababa, M., Nobile, M., Rolaz, A., Van Gool, F., Galli, M., ... & De Smedt, T. (2008). Pharmacological inhibition of nicotinamide phosphoribosyltransferase/visfatin enzymatic activity identifies a new inflammatory pathway linked to NAD. PloS one, 3(5), e2267.