背景资料 |
This gene encodes an transmembrane protein that functions as an ATP-dependent transporter of monoamines, such as dopamine, norepinephrine, serotonin, and histamine. This protein transports amine neurotransmitters into synaptic vesicles. Polymorphisms in this gene may be associated with schizophrenia, bipolar disorder, and other neurological/psychiatric ailments. |
研究类别 |
1. Erickson, J. D., Eiden, L. E., Hoffman, B. J. Expression cloning of a reserpine-sensitive vesicular monoamine transporter. Proc. Nat. Acad. Sci. 89: 10993-10997, 1992.2. Fon, E. A., Pothos, E. N., Sun, B.-C., Killeen, N., Sulzer, D., Edwards, R. H. Vesicular transport regulates monoamine storage and release but is not essential for amphetamine action. Neuron 19: 1271-1283, 1997. 3. Lin, Z., Walther, D., Yu, X.-Y., Li, S., Drgon, T., Uhl, G. R. SLC18A2 promoter haplotypes and identification of a novel protective factor against alcoholism. Hum. Molec. Genet. 14: 1393-1404, 2005. |