背景资料 |
CD99 antigen (Cluster of differentiation 99), also known as MIC2 or single-chain type-1 glycoprotein, is a heavily O-glycosylated transmembrane protein that is encoded by the CD99 gene in humans. The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. There is a related pseudogene located immediately adjacent to this locus. |
研究类别 |
1. Banting, G. S., Pym, B., Goodfellow, P. N. Biochemical analysis of an antigen produced by both human sex chromosomes. EMBO J. 4: 1967-1972, 1985. 2. Bernard, A., Aubrit, A., Raynal, B., Phan, D., Boumsell, L. A T cell surface molecule different from CD2 is involved in spontaneous rosette formation with erythrocytes. J. Immun. 140: 1802-1807, 1988. 3. Bixel, M. G., Li, H., Petri, B., Khandoga, A. G., Khandoga, A., Zarbock, A., Wolburg-Buchholz, K., Wolburg, H., Sorokin, L., Zeuschner, D., Maerz, S., Butz, S., Krombach, F., Vestweber, D. CD99 and CD99L2 act at the same site as, but independently of, PECAM-1 during leukocyte diapedesis. Blood 116: 1172-1184, 2010. |