E. coli-derived human BMP15 recombinant protein (Position: Q268-R392). Human BMP15 shares 69.6% amino acid (aa) sequence identity with mouse BMP15.
内容
500 ug/ml antibody with PBS ,0.02% NaN3 , 1 mg BSA and 50% glycerol.
纯化方式
Immunogen affinity purified.
浓度
500 ug/ml
产品形态
Liquid
保存条件
12 months from date of receipt,-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing.
背景资料
Bone morphogenetic protein 15 is a protein that in humans is encoded by the BMP15 gene. It's mainly involved in folliculogenesis. The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The transforming growth factor-beta superfamily includes large families of growth and differentiation factors. It is thought that this protein may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9. Defects in this gene are the cause of ovarian dysgenesis 2.
研究类别
1. Dube JL, Wang P, Elvin J, Lyons KM, Celeste AJ, Matzuk MM (Feb 1999). "The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes". Mol Endocrinol 12 (12): 1809–17.2. Persani, L.; Rossetti, R.; Di Pasquale, E.; Cacciatore, C.; Fabre, S. (2014). "The fundamental role of bone morphogenetic protein 15 in ovarian function and its involvement in female fertility disorders". Human Reproduction Update 20 (6): 869–883.
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[list_product_images]Western blot analysis of BMP15 expression in HELA whole cell lysates (lane 1) and MCF-7 whole cell lysates (lane 2). BMP15 at 56KD was detected using rabbit anti- BMP15 Antigen Affinity purified polyclonal antibody (Catalog # PB1103) at 0.5 μg/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002).[/list_product_images]