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广州威佳科技有限公司
100ul
货号 | PA1798 |
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产品名称 | Anti-TFPI Antibody |
基因名 | TFPI |
抗体来源 | Rabbit |
克隆 | Polyclonal |
抗体亚型 | Rabbit IgG |
分子量 | 45KD |
免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human TFPI(261-280aa QECLRACKKGFIQRISKGGL). |
内容 | 500 ug/ml antibody with PBS ,0.02% NaN3 , 1 mg BSA and 50% glycerol. |
纯化方式 | Immunogen affinity purified. |
浓度 | 500 ug/ml |
产品形态 | Liquid |
保存条件 | 12 months from date of receipt,-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing. |
背景资料 | TFPI(Tissue factor pathway inhibitor) also known as EPI, LACI, TFI and TFPT1 is a single-chain polypeptide which can reversibly inhibit Factor Xa(Xa) and Thrombin(Factor IIa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 nM. The gene for TFPI is located on chromosome 2q31-q32.1, and has nine exons which span 70 kb. TFPI has a relative molecular mass of 34,000 to 40,000 depending on the degree of proteolysis of the C-terminal region. |
研究类别 | 1. Enjyoji, K.-I., Emi, M., Mukai, T., Imada, M., Leppert, M. L., Lalouel, J. M., Kato, H.Human tissue factor pathway inhibitor (TFPI) gene: complete genomic structure and localization on the genetic map of chromosome 2q.Genomics 17: 423-428, 1993.2. Kleesiek, K., Schmidt, M., Gotting, C., Brinkmann, T., Prohaska, W.A first mutation in the human tissue factor pathway inhibitor gene encoding (P151L) TFPI. (Letter)Blood 92: 3976-3977, 1998.3. Lupu, C., Zhu, H., Popescu, N. I., Wren, J. D., Lupu, F.Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen.Blood 118: 4463-4471, 2011. |
Uniprot ID | TFPI: P10646 |
推荐配套的二抗和检测试剂 | Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P). *Blocking peptide 可以联系我们购买。 |
为了提供优质的抗体,博士德对每一批抗体都用没有转染过的细胞系和体细胞组织检测,以保证博士德出品的抗体有足够的亲和性足以和对应蛋白天然的表达含量起反应。
应用 | 稀释度* |
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Western blot(WB): | 1:500-2000 |
Immunohistochemistry(Paraffin-embedded Section): | 1:50-400 |
(Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
*稀释度需要用户自己调试,此处数据仅供参考。
**博士德提供高敏感的二抗和检测试剂盒。详情见相关产品推荐。
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