- ￥1960
- BOSTER
- BM5144-100ul
- 中国
- 2025年07月09日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 库存：
大量
- 供应商：
广州威佳科技有限公司
- 规格：
100ul
产品概况
| 货号 | BM5144 |
|---|---|
| 产品名称 | Anti-PCSK9 Antibody |
| 基因名 | PCSK9 |
| 抗体来源 | Rabbit |
| 克隆 | Monoclonal |
| 抗体亚型 | Rabbit |
| 分子量 | 62,78KD |
| 免疫原 | A synthesized peptide derived from human PCSK9 |
| 内容 | 500 ug/ml;Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500 ug/ml |
| 产品形态 | Liquid |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing. |
| 背景资料 | Proprotein convertase subtilisin/kexin type 9, also known as PCSK9, is an enzyme that in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. By genomic sequence analysis, PCSK9 was mapped to chromosome 1p32. This gene is a crucial player in the regulation of plasma cholesterol homeostasis. It may prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. PCSK9 can induce ubiquitination of LDLR leading to its subsequent degradation. This gene is involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. |
| 研究类别 | 1.Benjannet, S., Rhainds, D., Hamelin, J., Nassoury, N., Seidah, N. G.?The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications.?J. Biol. Chem. 281: 30561-30572, 2006.2.Cohen, J. C., Boerwinkle, E., Mosley, T. H., Jr., Hobbs, H. H.?Sequence variations in PCSK9,?low LDL, and protection against coronary heart disease.?New Eng. J. Med. 354: 1264-1272, 2006.3.Kathiresan, S., Melander, O., Anevski, D., Guiducci, C., Burtt, N. P., Roos, C., Hirschhorn, J. N., Berglund, G., Hedblad, B., Groop, L., Altshuler, D. M., Newton-Cheh, C., Orho-Melander, M.?Polymorphisms associated with cholesterol and risk of cardiovascular events.?New Eng. J. Med. 358: 1240-1249, 2008.4.Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Koseki, M., Pirruccello, J. P., Ripatti, S., Chasman, D. I., Willer, C. J., Johansen, C. T., Fouchier, S. W., and 197 others.?Biological, clinical and population relevance of 95 loci for blood lipids.?Nature 466: 707-713, 2010.loci for blood lipids.?Nature 466: 707-713, 2010. |
| Uniprot ID | PCSK9: Q8NBP7 |
产品应用细节
为了提供优质的抗体，博士德对每一批抗体都用没有转染过的细胞系和体细胞组织检测，以保证博士德出品的抗体有足够的亲和性足以和对应蛋白天然的表达含量起反应。
| 应用 | 稀释度* |
|---|---|
| Western blot(WB): | 1:500-2000 |
*稀释度需要用户自己调试，此处数据仅供参考。
**博士德提供高敏感的二抗和检测试剂盒。详情见相关产品推荐。
产品图片描述
点击图片放大风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验祝贺〖雅裕睿安〗成为Signalway Antibody(SAB)独家
antibody unconjugated； 货号21337，产品描述：GAPDH Antibody；规格 50 ul / 100 ul； 货号3052，产品描述：Rabbit anti-Human IgG secondary antibody HRP conjugated； 货号300904050，产品描述：One-Hour Western kit，10 ml / bottle x 3；
Large-scale immunofluorescence
containing 2% n-propyl gallate and 0.25 ug/ml Hoechst Primary antibodies rabbit anti-beta-gal antibody (Cappell Laboratories #0631-0002, at 1:200 dilution) rat monoclonal anti-yeast tubulin (YOL1/34; Sera-lab, at 1:100 dilution
2 n-propyl gallate and 0.25 ug/ml Hoechst Primary antibodies rabbit anti-beta-gal antibody (Cappell Laboratories #0631-0002, at 1:200 dilution) rat monoclonal anti-yeast tubulin (YOL1/34; Sera-lab, at 1:100 dilution
技术资料暂无技术资料 索取技术资料
