- ￥1960
- BOSTER
- BA2055-100ul
- 中国
- 2025年07月12日
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- 详细信息
- 技术资料
- 库存：
大量
- 供应商：
广州威佳科技有限公司
- 规格：
100ul
产品概况
| 货号 | BA2055 |
|---|---|
| 产品名称 | Anti-KCNA5 Antibody |
| 基因名 | KCNA5 |
| 抗体来源 | Rabbit |
| 克隆 | Polyclonal |
| 抗体亚型 | Rabbit IgG |
| 分子量 | 67KD |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human KCNA5 (583-613aa LEKCNVKAKSNVDLRRSLYALCLDTSRETDL), different from the related mouse and rat sequences by two amino acids. |
| 内容 | 500 ug/ml antibody with PBS ，0.02% NaN3 , 1 mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500 ug/ml |
| 产品形态 | Liquid |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing. |
| 背景资料 | Potassium voltage-gated channel, shaker-related subfamily, member 5, also known as KCNA5 or Kv1.5, is a protein that in humans is encoded by the KCNA5 gene. Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. KCNA5 encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization, thereby contributing to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Mutations in this gene have been related to both atrial fibrillation and sudden cardiac death. KCNA5 are also key players in pulmonary vascular function, where they play a role in setting the resting membrane potential and its involvement during hypoxic pulmonary vasoconstriction. |
| 研究类别 | 1. Nielsen, NH; Winkel BG, Kanters JK, Schmitt N, Hofman-Bang J, Jensen HS, Bentzen BH, Sigurd B, Larsen LA, Andersen PS, Hauns S, Kjeldsen K, Grunnet M, Christiansen M, Olesen SP (March 2007). "Mutations in the Kv1.5 channel gene KCNA5 in cardiac arrest patients". Biochem Biophys Res Commun 354 (3): 776–82.2. Olson, TM; Alekseev AE; Liu XK; Park S; Zingman LV; Bienengraeber M; Sattiraju S; Ballew JD; Jahangir A; Terzic A (July 2006). "Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation". Hum Mol Genet 15 (14): 2185–91. |
| Uniprot ID | KCNA5: P22460 |
| 推荐配套的二抗和检测试剂 | Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P). *Blocking peptide 可以联系我们购买。 |
产品应用细节
为了提供优质的抗体，博士德对每一批抗体都用没有转染过的细胞系和体细胞组织检测，以保证博士德出品的抗体有足够的亲和性足以和对应蛋白天然的表达含量起反应。
| 应用 | 稀释度* |
|---|---|
| Western blot(WB): | 1:500-2000 |
| Immunohistochemistry in paraffin section (IHC): | 1:50-400 |
| (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. | |
*稀释度需要用户自己调试，此处数据仅供参考。
**博士德提供高敏感的二抗和检测试剂盒。详情见相关产品推荐。
产品图片描述
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[list_product_images]KCNA5(BA2055)(MW:67KD, 100KD)心肌, 脑, 骨骼肌, 胎盘, HELA, HT1080, SMMC细胞裂解, 免疫印迹分析.|KCNA5(BA2055)乳癌标本, 石蜡切片, SABC法, DAB显色.[/list_product_images]
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Anti-KCNA5 Antibody(BA2055-100ul)
￥1960
