- ￥1960
- BOSTER
- A02230-1-100ul
- 中国
- 2025年07月12日
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- 技术资料
- 库存：
大量
- 供应商：
广州威佳科技有限公司
- 规格：
100ul
产品概况
| 货号 | A02230-1 |
|---|---|
| 产品名称 | Anti-CHRNA4 Antibody |
| 基因名 | CHRNA4 |
| 抗体来源 | Rabbit |
| 克隆 | Polyclonal |
| 抗体亚型 | Rabbit IgG |
| 分子量 | 70KD |
| 免疫原 | A synthetic peptide corresponding to a sequence of human CHRNA4 (HVETRAHAEERLLKKLFSGYNKWSRPVANISD). |
| 内容 | 500 ug/ml antibody with PBS ，0.02% NaN3 , 1 mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500 ug/ml |
| 产品形态 | Liquid |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing. |
| 背景资料 | Neuronal acetylcholine receptor subunit alpha-4, also known as nAChRα4, is a protein that in humans is encoded by the CHRNA4 gene. This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. |
| 研究类别 | 1. "Entrez Gene: CHRNA4 cholinergic receptor, nicotinic, alpha 4".2. Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–7.3. Hirose S, Iwata H, Akiyoshi H, et al. (1999). "A novel mutation of CHRNA4 responsible for autosomal dominant nocturnal frontal lobe epilepsy.".Neurology. 53 (8): 1749–53. |
| Uniprot ID | CHRNA4: P43681 |
| 推荐配套的二抗和检测试剂 | Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P). *Blocking peptide 可以联系我们购买。 |
产品应用细节
为了提供优质的抗体，博士德对每一批抗体都用没有转染过的细胞系和体细胞组织检测，以保证博士德出品的抗体有足够的亲和性足以和对应蛋白天然的表达含量起反应。
| 应用 | 稀释度* |
|---|---|
| Western blot(WB): | 1:500-2000 |
*稀释度需要用户自己调试，此处数据仅供参考。
**博士德提供高敏感的二抗和检测试剂盒。详情见相关产品推荐。
产品图片描述
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[list_product_images]Figure 1. Western blot analysis of CHRNA4 using anti-CHRNA4 antibody (A02230-1). Lane 1: human Hela cell lysate,Lane 2: human COLO-320 cell lysate,Lane 3: human HepG2 cell lysate,Lane 4: human PANC-1 cell lysate,Lane 5: human 22RV1 cell lysate,Lane 6: human SGC-7901 cell lysate,Lane 7: rat spleen tissue lysate,Lane 8: mouse spleen tissue lysate. anti-CHRNA4 antigen affinity purified polyclonal antibody (Catalog # A02230-1)probed with a goat anti-rabbit IgG-HRP secondary antibody The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) . A specific band was detected for CHRNA4 at approximately 70KD. The expected band size for CHRNA4 is at 70KD.[/list_product_images]
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Anti-Nicotinic Acetylcholine Receptor alpha 4/CHRNA4 Antibody(A02230-1-100ul)
￥1960
