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- MA01962-50ul
- 中国
- 2025年07月16日
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- 库存：
大量
- 供应商：
广州威佳科技有限公司
- 规格：
50ul
产品概况
| 货号 | MA01962 |
|---|---|
| 产品名称 | Anti-Tigit Antibody (Clone#OTI3B6) |
| 基因名 | TIGIT |
| 抗体来源 | Mouse |
| 克隆 | OTI3B6 |
| 抗体亚型 | Mouse IgG1 |
| 分子量 | 26.1KD |
| 免疫原 | Full length human recombinant protein of human TIGIT (NP_776160) produced in HEK293T cell. |
| 内容 | PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| 纯化方式 | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| 浓度 | 500 ug/ml |
| 产品形态 | Liquid |
| 保存条件 | Stable for 12 months from date of receipt. Store at -20°C as received. |
| 背景资料 | This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses. [provided by RefSeq, Sep 2009] |
| 研究类别 | 1. Gross, M. B. Personal Communication. Baltimore, Md. 6/16/2009. 2. Stanietsky, N., Simic, H., Arapovic, J., Toporik, A., Levy, O., Novik, A., Levine, Z., Beiman, M., Dassa, L., Achdout, H., Stern-Ginossar, N., Tsukerman, P., Jonjic, S., Mandelboim, O. The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proc. Nat. Acad. Sci. 106: 17858-17863, 2009. 3. Yu, X., Harden, K., Gonzalez, L. C., Francesco, M., Chiang, F., Irving, B., Tom, I., Ivelja, S., Refino, C. J., Clark, H., Eaton, D., Grogan, J. L. The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nature Immun. 10: 48-57, 2009. |
| Uniprot ID | TIGIT: P86176 |
产品应用细节
为了提供优质的抗体，博士德对每一批抗体都用没有转染过的细胞系和体细胞组织检测，以保证博士德出品的抗体有足够的亲和性足以和对应蛋白天然的表达含量起反应。
| 应用 | 稀释度* |
|---|---|
| Western blot (WB): | 1:1000 |
| Flow cytometry (FCM): | 1:100 |
*稀释度需要用户自己调试，此处数据仅供参考。
**博士德提供高敏感的二抗和检测试剂盒。详情见相关产品推荐。
产品图片描述
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[list_product_images]Figure 1. Flow cytometric analysis of living 293T cells transfected with TIGIT overexpression plasmid , Red)/empty vector (Blue) using anti-TIGIT antibody. Cells incubated with a non-specific antibody (Green) were used as isotype control (1:100).|Figure 2. HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TIGIT (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TIGIT (1:1000).[/list_product_images]
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Anti-Tigit Antibody (Clone#OTI3B6)(MA01962-50ul)
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