Anti-Neurocan/NCAN Antibody(A06700-2-50ul)

Anti-Neurocan/NCAN Antibody(A0

6700-2-50ul)
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  • ¥1180
  • BOSTER已认证
  • A06700-2-50ul
  • 中国
  • 2025年07月12日
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    • 详细信息
    • 技术资料
    • 库存

      大量

    • 供应商

      广州威佳科技有限公司

    • 规格

      50ul

    产品概况

    货号 A06700-2
    产品名称 Anti-NCAN Antibody
    基因名 NCAN
    抗体来源 Rabbit
    克隆 Polyclonal
    抗体亚型 Rabbit IgG
    分子量 143KD
    免疫原 E.coli-derived human Neurocan/NCAN recombinant protein (Position: H1140-A1179).
    内容 500 ug/ml antibody with PBS ,0.02% NaN3 , 1 mg BSA and 50% glycerol.
    纯化方式 Immunogen affinity purified.
    浓度 500 ug/ml
    产品形态 Liquid
    保存条件 12 months from date of receipt,-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing.
    背景资料 Neurocan core protein is a protein that in humans is encoded by the NCAN gene. Neurocan is a member of the lectican / chondroitin sulfate proteoglycan protein families and consists of neurocan core protein and chondroitin sulfate. It is thought to be involved in the modulation of cell adhesion and migration. In the human subjects, it was found that NCAN genotype was strongly associated with manic symptoms but not with depressive symptoms. In the mice, the absence of functional Neurocan resulted in a variety of manic-like behaviors, which could be normalized by administering lithium.
    研究类别 1. Miró X, Meier S, Dreisow ML, Frank J, Strohmaier J, Breuer R, Schm?l C, Albayram ?, Pardo-Olmedilla MT, Mühleisen TW, Degenhardt FA, Mattheisen M, Reinhard I, Bilkei-Gorzo A, Cichon S, Seidenbecher C, Rietschel M, N?then MM, Zimmer A (September 2012). "Studies in humans and mice implicate neurocan in the etiology of mania". Am J Psychiatry. 169 (9): 982–90.2. Rauch U, Karthikeyan L, Maurel P, Margolis RU, Margolis RK (Oct 1992). "Cloning and primary structure of neurocan, a developmentally regulated, aggregating chondroitin sulfate proteoglycan of brain". J Biol Chem. 267 (27): 19536–47.
    Uniprot ID NCAN: O14594
    推荐配套的二抗和检测试剂 Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.

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    [list_product_images]Figure 1. Western blot analysis of anti- Neurocan/NCAN antibody (A06700-2). The sample well of each lane was loaded with 50ug of sample under reducing conditions.
    Lane 1: rat brain tissue lysates,
    Lane 2: mouse brain tissue lysates.
    Use rabbit anti- Neurocan/NCAN 1:1000, probed with a goat anti-rabbit IgG-HRP secondary antibody. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002). A specific band was detected for Neurocan/NCAN at approximately 143KD. The expected band size for Neurocan/NCAN is at 136KD.[/list_product_images]

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