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- BOSTER
- M00124-50ul
- 中国
- 2025年07月08日
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- 详细信息
- 技术资料
- 库存：
大量
- 供应商：
广州威佳科技有限公司
- 规格：
50ul
产品概况
| 货号 | M00124 |
|---|---|
| 产品名称 | Anti- IL-18 Antibody(monoclonal, AGOO-9) |
| 基因名 | Il18 |
| 抗体来源 | Rat |
| 克隆 | Monoclonal(Clone:AGOO-9) |
| 抗体亚型 | Rat IgG2a, κ |
| 分子量 | 22KD |
| 免疫原 | Not available or unknown |
| 内容 | 200 ug/ml antibody with PBS ，0.02% NaN3 , 1 mg BSA and 50% glycerol. |
| 纯化方式 | protein G purified. |
| 浓度 | 200 ug/ml |
| 产品形态 | Liquid |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing. |
| 背景资料 | Interleukin-18 also known as IL18 is a protein which in humans is encoded by the IL18 gene. The protein encoded by this gene is a proinflammatory cytokine.IL-18 is a cytokine produced by macrophages and other cells that belongs to the IL-1 superfamily. IL-18 works by binding to the interleukin-18 receptor, and together with IL-12 it induces cell-mediated immunity following infection with microbial products like lipopolysaccharide(LPS). After stimulation with IL-18, natural killer(NK) cells and certain T cells release another important cytokine called interferon-gamma(IFN-gamma) or type II interferon that plays an important role in activating the macrophages or other cells.The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production in B cells. IL-18 binding protein(IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci. |
| Uniprot ID | Il18: P70380 |
| 推荐配套的二抗和检测试剂 | Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1001) for Western blot. |
产品应用细节
为了提供优质的抗体，博士德对每一批抗体都用没有转染过的细胞系和体细胞组织检测，以保证博士德出品的抗体有足够的亲和性足以和对应蛋白天然的表达含量起反应。
| 应用 | 稀释度* |
|---|---|
| Western blot(WB): | 1:500-2000 |
*稀释度需要用户自己调试，此处数据仅供参考。
**博士德提供高敏感的二抗和检测试剂盒。详情见相关产品推荐。
产品图片描述
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[list_product_images]Figure 1. Western blot analysis of IL-18 using anti- IL-18 antibody (M00124).
The sample well of each lane was loaded with 50ug of sample under reducing conditions.
Lane 1: recombinant mouse IL-18 protein 15ng,
Lane 2: recombinant mouse IL-18 protein 10ng.
Use rat anti-IL-18 1:1000, probed with a goat anti- rat IgG-HRP secondary antibody. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1004).[/list_product_images]
The sample well of each lane was loaded with 50ug of sample under reducing conditions.
Lane 1: recombinant mouse IL-18 protein 15ng,
Lane 2: recombinant mouse IL-18 protein 10ng.
Use rat anti-IL-18 1:1000, probed with a goat anti- rat IgG-HRP secondary antibody. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1004).[/list_product_images]
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Anti- IL-18 Antibody(M00124-50ul)
￥1180
