- ￥1180
- BOSTER
- PB0347-50ul
- 中国
- 2025年07月14日
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- 详细信息
- 技术资料
- 库存：
大量
- 供应商：
广州威佳科技有限公司
- 规格：
50ul
产品概况
| 货号 | PB0347 |
|---|---|
| 产品名称 | Anti-PER2 Antibody |
| 基因名 | PER2 |
| 抗体来源 | Rabbit |
| 克隆 | Polyclonal |
| 抗体亚型 | Rabbit IgG |
| 分子量 | 130KD/137KD |
| 免疫原 | E.coli-derived human PER2 recombinant protein (Position: N13-K330). Human PER2 shares 84% and 83% amino acid (aa) sequence identity with mouse and rat PER2, respectively. |
| 内容 | 500 ug/ml antibody with PBS ，0.02% NaN3 , 1 mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500 ug/ml |
| 产品形态 | Liquid |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing. |
| 背景资料 | The PER2 gene encodes the period circadian protein homolog 2 protein in humans. This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. PER2 is mapped to 2q37.3. It has been showed that PER2 can positively stimulate activity of the Bmal1-Npas2 transcription complex and, in turn, Npas2 transcriptionally regulates delta-aminolevulinate synthase. PER2 is involved in a negative-feedback loop that attenuates estrogen stimulation and links the circadian cycle to estrogen receptor signaling. The rhythmic levels of PER2 are critical for circadian oscillations in cells and intact organisms. What’s more, the PER2 gene also functions in tumor suppression by regulating DNA damage-responsive pathways. |
| 研究类别 | 1. Chen, R., Schirmer, A., Lee, Y., Lee, H., Kumar, V., Yoo, S.-H., Takahashi, J. S., Lee, C. Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism. Molec. Cell 36: 417-430, 2009.2. Fu, L., Pelicano, H., Liu, J., Huang, P., Lee, C. C. The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell 111: 41-50, 2002. Note: Erratum: 111: 1055 only, 2002. 3. Gery, S., Virk, R. K., Chumakov, K., Yu, A., Koeffler, H. P. The clock gene Per2 links the circadian system to the estrogen receptor. Oncogene 26: 7916-7920, 2007. |
| Uniprot ID | PER2: O15055 |
| 推荐配套的二抗和检测试剂 | Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P). *Blocking peptide 可以联系我们购买。 |
产品应用细节
为了提供优质的抗体，博士德对每一批抗体都用没有转染过的细胞系和体细胞组织检测，以保证博士德出品的抗体有足够的亲和性足以和对应蛋白天然的表达含量起反应。
| 应用 | 稀释度* |
|---|---|
| Western blot(WB): | 1:500-2000 |
*稀释度需要用户自己调试，此处数据仅供参考。
**博士德提供高敏感的二抗和检测试剂盒。详情见相关产品推荐。
产品图片描述
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[list_product_images]Figure 1. Western blot analysis of anti- PER2 antibody (PB0347). The sample well of each lane was loaded with 50ug of sample under reducing conditions.
Lane 1: human K562 whole cell lysates,
Lane 2: human Hela whole cell lysates.
Use rabbit anti- PER2 1:1000, probed with a goat anti-rabbit IgG-HRP secondary antibody. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002). A specific band was detected for PER2 at approximately 130KD. The expected band size for PER2 is at 137KD. [/list_product_images]
Lane 1: human K562 whole cell lysates,
Lane 2: human Hela whole cell lysates.
Use rabbit anti- PER2 1:1000, probed with a goat anti-rabbit IgG-HRP secondary antibody. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002). A specific band was detected for PER2 at approximately 130KD. The expected band size for PER2 is at 137KD. [/list_product_images]
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Anti-PER2 Antibody(PB0347-50ul)
￥1180
