- ￥1180
- BOSTER
- BM5437-50ul
- 中国
- 2025年07月13日
企业认证
相关产品推荐更多 >
Anti-Cofilin 2/CFL2 Antibody (monoclonal, 8C13)(M04773-100ul)
￥1960
Anti-Phospho-Raf1 (S43) Rabbit Monoclonal Antibody(BM4802-50ul)
￥1180Anti-ACADM/Mcad Rabbit Monoclonal Antibody(BM4163-100ul)
￥1960Anti-Human Neurexin 1 DyLight 488 conjugated Antibody(A01490-Dyl488-100ul)
￥2380Anti-COX2/Cyclooxygenase 2/PTGS2 Antibody (Clone#OTI4C4)(M00084-5-50ul)
￥1180
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 库存：
大量
- 供应商：
广州威佳科技有限公司
- 规格：
50ul
产品概况
| 货号 | BM5437 |
|---|---|
| 产品名称 | Anti-PTTG1 Antibody |
| 基因名 | PTTG1 |
| 抗体来源 | Rabbit |
| 克隆 | Monoclonal |
| 抗体亚型 | Rabbit |
| 分子量 | 22KD/28KD |
| 免疫原 | A synthesized peptide derived from human Securin Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. |
| 内容 | 500 ug/ml;Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500 ug/ml |
| 产品形态 | Liquid |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing. |
| 背景资料 | Securin, also known as pituitary tumor-transforming 1 or EAP1 is a protein that in humans is encoded by the PTTG1 gene. PTTG1 gene is mapped to 5q33.3. The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex(APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box(D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. |
| 研究类别 | 1. Holt, L. J., Krutchinsky, A. N., Morgan, D. O. Positive feedback sharpens the anaphase switch. Nature 454: 353-357, 2008.2. Ying, H., Furuya, F., Zhao, L., Araki, O., West, B. L., Hanover, J. A., Willingham, M. C., Cheng, S. Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone beta-receptor inhibits mitotic progression. J. Clin. Invest. 116: 2972-2984, 2006. |
| Uniprot ID | PTTG1: O95997 |
产品应用细节
为了提供优质的抗体，博士德对每一批抗体都用没有转染过的细胞系和体细胞组织检测，以保证博士德出品的抗体有足够的亲和性足以和对应蛋白天然的表达含量起反应。
| 应用 | 稀释度* |
|---|---|
| Western blot(WB): | 1:500-2000 |
*稀释度需要用户自己调试，此处数据仅供参考。
**博士德提供高敏感的二抗和检测试剂盒。详情见相关产品推荐。
产品图片描述
点击图片放大
[list_product_images]Western blot analysis of Securin expression in HeLa cell lysate.[/list_product_images]
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
Anti-Securin Monoclonal Antibody(BM5437-50ul)
￥1180
