RN-9893,2109450-40-8

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RN-9893 hydrochloride

CAS No. : 2109450-40-8

MCE 国际站：RN-9893 hydrochloride

产品活性：RN-9893 (Hydrochloride) 是一种具有口服活性的 TRPV4 拮抗剂，在人和大鼠体内的 IC₅₀ 值分别为 0.42 μM 和 0.66 μM。RN-9893 (Hydrochloride) 降低 4α-PDD 和 20% hypotonicity 诱导的大鼠 TRPV4 活性。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：TRP Channel

In Vitro: RN-9893 (Hydrochloride) reveals selectivity towards TRPV1 (IC₅₀: 10 μM), TRPV3 (IC₅₀: >30 μM) and TRPM8 (IC₅₀: 30 μM) .
RN-9893 (Hydrochloride) inhibits rTRPV4 with an IC₅₀ of 0.57 μM when 4α-PDD acts as an agonist. RN-9893 inhibits rTRPV4 with an IC₅₀ of 2.1 μM when hypotonicity is used as agonist.

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