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- 2025年12月05日
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E3 ligase Ligand-Linker Conjugate 43
MCE 国际站：E3 ligase Ligand-Linker Conjugate 43
产品活性：E3 ligase Ligand-Linker Conjugate 43 是 E3 连接酶配体与连接子的缀合物 (E3 Ligase Ligand-Linker Conjugates)，由 Thalidomide (HY-14658) 和对应 Linker 构成。E3 ligase Ligand-Linker Conjugate 43 可作为 Cereblon 配体募集 CRBN 蛋白，并作为关键中间体进行完整 PROTACs 分子合成。
作用靶点：Ligands for E3 Ligase | Autophagy
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文献和实验Attachment of Reporter and Conjugate Groups to the 3′ Termini of Oligonucleotides
Figure 4.5.1 Generic oligonucleotide 3′‐conjugate. View Image
Modification of the 5′ Terminus of Oligonucleotides for Attachment of Reporter and Conjugate Groups
; Fmoc, 9‐fluorenylmethyl; L, linker; MMTr, monomethoxytrityl; Px,9‐phenylxanthen‐9‐yl(pixyl); R, oligodeoxynucleotide; R′, protected oligonucleotide; TCEP, tris‐(2‐carboxyethyl)phosphine; Tr, trityl; Z, functional group or ligand; Z′, protected
by fluorescent image analysis. Herein, we demonstrated that the method allows analysis of the intracellular protein stability as regulated by protein-degradation signals or an exogenously expressed E3 ubiquitin ligase.
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