Recombinant Human Organic Cati

Production of Cells with Targeted Integration of Gene Variants of Human ABC Transporter for Stable and Regulated Expression Using the Flp Recombinase

randomly at unpredictable sites in the host’s chromosomal DNA, and the number of integrated recombinant DNAs is not controllable. To overcome this problem, we developed the Flp-In method to integrate one single copy of cDNA encoding the human ABC

In vitro Assessment of Transporter-Mediated Uptake in Plated Cryopreserved Hepatocytes

in an organic solvent such as methanol or DMSO to desired concentration, such as 1 mM. 2. In separate conical tubes, add the test compounds and positive control(s) to warm Incubation Medium to yield the desired working concentration(s). For example

In Vitro Characterization of Renal Transporters OAT1, OAT3, and OCT2

The human transporters organic anion transporter 1 (OAT1), organic anion transporter 3 (OAT3) and organic cation transporter 2 (OCT2) are membrane proteins involved in the renal clearance of substances from the body. While the original