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文献和实验. Here, we describe a delivery system based on the yeast Saccharomyces cerevisiae that allows the delivery of functional messenger RNA to mammalian antigen-presenting cells such as human dendritic cells. Further, we present a method to prove antigen processing and presentation
Uptake of Antigen-Antibody Complexes by Human Dendritic Cells
Fc receptors specific for IgG (FcγR) potentiate the immune response by facilitating the interaction between myeloid cells and antibody-coated targets (1 -3 ). Monocyte and neutrophil FcyR engagement can lead to the induction of lytic-type
Assessing Antigen-Specific CD8+ CTL Responses in Humans
recognized by NP-specific CTL in a major histocompatability complex (MHC) class I restricted manner (5 ,6 ). Bjorkman et al. (6 ,7 ) subsequently resolved the structure of the human class I molecule HLA-A2 by x-ray crystallography and provided evidence
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