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- Biomatik
- RPU53222
- 2025年07月14日
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文献和实验The human CYP1 family consists of at least three proteins, CYP1A1, CYP1A2, and CYP1B1 (1 ), CYP1A1 is absent or present at very low levels in human liver (2 , 3 ), but its expression is readily detectable in lung (4 , 5 ). By contrast
Phenotyping UDP-Glucuronosyltransferases (UGTs) Involved in Human Drug Metabolism: An Update
Glucuronidation, catalyzed by the UDP-glucuronosyltransferases (UGT), is a major drug clearance mechanism in humans and other mammalian species. UGT reaction phenotyping involves determining which of the 19 known human UGTs are primarily
In Vitro Identification of UDP-Glucuronosyltransferases (UGTs) Involved in Drug Metabolism
in the prediction of adverse reactions resulting from drug-drug interactions or genetic polymorphism. An integrated approach is proposed for UGT reaction phenotyping using recombinant enzymes and human liver microsomes. Described methods include screening
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