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文献和实验Immunostaining Human Paraffin-Embedded Sections for Mismatch Repair Proteins
The loss of the function in any one of four human DNA mismatch repair genes, hMSH2, hMLH1, hPMS1 , and hPMS2 , is thought to lead to deficient mismatch repair (MMR) of DNA in the somatic cells leading to increased mutations and thereby cancer
Impact of Breast Cancer Resistance Protein on Cancer Treatment Outcomes
Breast cancer resistance protein (BCRP/ABCG2) was discovered in multidrug resistant breast cancer cells having an ATP-dependent transport-based resistance phenotype. This ABC transporter functions (at least in part) as a xenobiotic protective
PriCells: Introduction of Isolation and Culture of Human Alveolar Epithelial Cells
with patterns that match those of rodent T1α. However, the human data are unclear, because antibodies to rodent T1α do not recognize ATI cell antigens in normal adult human lung. This likely indicates that O-glycosylation of the human protein(s
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