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文献和实验Overview of Protein Microarrays
. Hu, S., Xie, Z., Onishi, A., Yu, X., Jiang, L., Lin, J., Rho, H.‐s., Woodard, C., Wang, H., and Jeong, J.‐S. 2009. Profiling the human protein‐DNA interactome reveals ERK2 as a transcriptional repressor
Nature Methods-让胚胎干细胞茁壮成长,一个神奇的小分子配方介绍
中发现,ROCK(Rho-associated Coiled-coil-forming protein serine/threonine Kinase)通路的抑制剂Y-27632能够改善人源胚胎干细胞(hESCs)的生存状态,抑制细胞凋亡。目前,Y-27632已经被广泛运用应用于优化人源干细胞的培养。可惜的是,Y-27632对于细胞活力及生存率提升有限,我们仍然需要找寻更高效的方法来解决这个问题。 2021年5月初,NIH的陈宁博士等在Nature Methods发表
system proceeds through at least three different pathways, which mediate the flow of mitogenic and survival-promoting signals. One of the pathways proceeds through protein tyrosine kinase activity, Ras and the MAPK (Mitogen-Activated Protein Kinase) cascade
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