- ￥1794
- PeproTech
- 500-P278-50UG
- 2025年07月11日
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50ug
Rabbit Anti-Murine IL-21 (50ug)
IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation.
Its action generally enhances antigen-specific responses of immune cells. The biological effects
of IL-21 include: inducing the differentiation of T-cell-stimulated B-cells into plasma cells and
memory B-cells; the stimulation of IgG production in conjunction with IL-4; and the induction
of apoptotic effects in naïve B-cells and stimulated B-cells in the absence of T-cell signaling.
Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts
its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the g
chain (gc) found in other cytokine receptors, including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/
IL-21R interaction triggers a cascade of events, which includes activation of the tyrosine kinases
JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.
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Rabbit Anti-Murine IL-21 (50ug)
￥1794
