Human CDNF (25ug)

Human CDNF (25ug)

CDNF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. CDNF and its structural homolog, MANF, each contain an N-terminal saposin like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. CDNF and MANF can prevent 6-OHDA-induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson’s disease.