- ￥7030
- PeproTech
- 200-39-100UG
- 2025年07月14日
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100ug
Human IL-37 (IL-1F7) (100ug)
The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-
37 (IL-1F7), which acts as a modulator of the immune response. Reduction of IL-37 synthesis
in PBMCs leads to increased production of pro-inflammatory cytokines including IL-1 alpha,
IL-1 beta, IL-6 and TNF-alpha. The role of IL-37 as an inhibitor of the innate inflammatory
response is also corroborated by the observation that it is highly expressed in synovial tissue
from patients with rheumatoid arthritis. Full length IL-37 resides primarily in the cytoplasm,
but after activation through cleavage by CASP1, it can translocate to the nucleus where it exerts
its activity by direct interaction with SMAD3.
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Human IL-37 (IL-1F7) (100ug)
￥7030
