- ￥30996
- PeproTech
- 100-53-1MG
- 2025年07月04日
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1mg
Human Klotho (1mg)
Klotho is a glycosylated protein that plays an important role in the regulation of phosphate and
calcium homeostasis. Human Klotho exists in both membrane bound and secreted forms, and is
predominantly expressed in the kidney convoluted tubules, and, to a lesser extent, in the brain,
reproductive organs, endocrine glands, urinary bladder, skeletal muscle, placenta, and colon. The
full length transmembrane form has a large extracellular domain composed of two homologous
subunits termed KL1 and KL2, which contain 516 and 439 amino acid residues, respectively.
The predominant circulating form, which is derived from alternative RNA splicing, contains the
KL1 subunit and constitutes the N-terminal sequence of transmembrane Klotho. A third Klotho
protein of about 128 kDa has been identified in the blood and cerebrospinal fluid. This circulating
protein arises from the action of an as yet unidentified protease, which cleaves transmembrane
Klotho just above and/or within the plasma membrane. Klotho has been shown to play a key role
in the signaling cascade of fibroblast growth factor-23 (FGF-23), a bone-derived hormone that acts
in the kidney to inhibit phosphate reabsorption and vitamin D biosynthesis. Klotho promotes
FGF-23 signaling through binding to FGFRI (IIIc) which converts this canonical FGF receptor
into a specific receptor for FGF-23. In the absence of Klotho the function of FGF-23 is literally
abolished.
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Human Klotho (1mg)
￥30996
