产品名称:Human ACE2-HRP
产品货号:AI04505C
产品类型:Antigen
来源:The recombinant protein is expressed from HEK293 cells.
纯度:> 95% as determined by SDS-PAGE
应用平台:ELISA
缓冲液系统:50mM Tris-HCl, 0.15M NaCl, pH 8.0
重构方法:Please see Certificate of Analysis (COA) for which is sent along with the products.
运输:Recombinant proteins in liquid form are transported in frozen form with blue ice.
存储:
For long term storage, the product is stable for up to two years by stored at -20℃ or lower.
Please use the product (liquid form) within 2 weeks if it is stored at 2-8℃.
Please avoid repeated freeze-thaw cycles.
Please contact us for any concerns.
背景介绍
新型冠状*病毒(SA*RS-CoV-2)纤突( Spike,S)糖蛋白由1273个氨基酸组成,其相对分子质量为141178.47,含有一个跨膜区,
是低亲水性分泌蛋白。S蛋白的基本组成单位为纤突蛋白,其二级结构中以无规则卷曲和螺旋结构为主,三级结构中纤突糖蛋白和
ACE2复合体具有重要的意义。
新冠*病毒S蛋白有两个亚基:S1和S2,受体结合位点(RBD)位于S1亚基上。S1亚基是S蛋白与宿主细胞膜相互作用的“门户”,
即功能发挥区;S2亚基在S1亚基的激活下,能加强S1与宿主细胞的融合,进而促进SA*RS-CoV-2在宿主细胞的增殖,即功能辅助区;
它以三聚体的形式组成病毒粒子外膜表面的刺突,其主要功能是识别宿主细胞表面受体,与宿主细胞发生融合并实现传播,S蛋白是
疫苗、治疗性抗体以及临床诊断的潜在靶点。