Recombinant 2019-nCov S Protei

Methods to Study the Ras2 Protein Activation State and the Subcellular Localization of Ras-GTP in Saccharomyces cerevisiae

-GTP in vivo in single S. cerevisiae cells, we expressed a probe consisting of a GFP fusion with a trimeric Ras Binding Domain of Raf1 (eGFP-RBD3), which was proven to be a useful live-cell biosensor for Ras-GTP in mammalian cells.

聊一聊血清学研究中的表面封闭剂

. Blackwell Scientific Publications, Oxford 3: Tai, W et al. (2020) Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine. Cell Mol Immunol

从血浆疗法到抗体疫苗，战胜新冠肺炎，或许不用等太久了！

在极短时间内研发与量产病毒特异性抗体和疫苗成为新型冠状肺炎治疗和预防困境。图源：中国临床试验注册中心官网结构生物学助力第一时间解析新型冠状病毒 S 蛋白和人 ACE2 全长结构，有助于我们理解新型冠状病毒感染靶细胞的结构基础和功能特征，为发现和优化阻断新型冠状病毒感染细胞的特异性药物奠定了坚实基础。图源：上、中 bioRxiv 官网，下 Science 官网西湖大学周强团队成功解析了完整 ACE2 蛋白与新型冠状病毒 S 蛋白受体结构域 RBD 复合体结构（感兴趣可戳：西湖大学成功解析新冠病毒入侵