Anti-2019-nCoV S-cIgG1 Neutral

已验证样本 in ELISA: Recombinant 2019-nCoV S-trimer Protein (C-6His), Recombinant Recombinant 2019-nCoV S Protein RBD-SD1 (C-6His)

ELISA: 1:1,000-1:2,000

Monoclonal

IgG1

Recombinant 2019-nCoV S-trimer Protein (His Tag)

1 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS, pH 7.4

8A5

Unconjugated

Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SA/RS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major 免疫原 and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.