DCX Polyclonal Antibody 货号：E-A

Verified Samples in IHC: Mouse brain, Rat brain

IHC 1:500-1:2000

Polyclonal

IgG

KLH conjugated Synthetic peptide corresponding to Mouse DCX

DCX

DBCN, DC, DCX, Dbct, Doublecortex, Doublin, FLJ51296, LISX, Lis X, Lis-X, Lissencephalin X, Lissencephalin-X, Lissencephaly X linked, Lissencephaly X linked doublecortin, Neuronal migration protein doublecortin, OTTHUMP00000023859, OTTHUMP00000023860, OTTHUMP000002163

O88809, Q9ESI7

Cytoplasm.

0.93 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH 7.4.

Affinity purification

Cancer, Neuroscience, Tags and Cell Markers

Unconjugated

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.