- ￥420 - 2365
- Elabscience
- E-AB-15441
- 湖北武汉
- 2025年07月30日
- WB;ELISA
- Rabbit
- Human;Mouse;Rat
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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
AKT1 Polyclonal Antibody_货号:E-AB-15441_多克隆抗体
- 抗体英文名：
AKT1 Polyclonal Antibody
- 应用范围：
WB;ELISA
- 宿主：
Rabbit
- 适应物种：
Human;Mouse;Rat
- 保质期：
12个月
- 目录编号：
E-AB-15441
- 级别：
科研级别
- 库存：
999
- 供应商：
武汉伊莱瑞特生物科技股份有限公司
- 标记物：
Unconjugated
- 克隆性：
Polyclonal
- 保存条件：
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
- 形态：
液体
- 亚型：
IgG
- 规格：
200μL/120μL/60μL/20μL
| 规格： | 200μL | 产品价格： | ￥2365.0 |
|---|---|---|---|
| 规格： | 120μL | 产品价格： | ￥1640.0 |
| 规格： | 60μL | 产品价格： | ￥1010.0 |
| 规格： | 20μL | 产品价格： | ￥420.0 |
货号：E-AB-15441
| Verified Samples |
Verified Samples in WB:NIH/3T3
|
| Dilution |
WB 1:500-1:1000
|
| Clonality |
Polyclonal
|
| Isotype |
IgG
|
| Immunogen |
Synthetic peptide of human pan-AKT
|
| Abbre |
pan-AKT
|
| Synonyms |
AKT 1;AKT;AKT1;AKT1;MGC99656;PKB;PKB-ALPHA;PRKBA;Protein Kinase B Alpha;Protein kinase B;Proto-oncogene c-Akt;RAC Alpha;RAC;RAC-alpha serine/threonine-protein kinase;RAC-PK-alpha抗体
|
| Swissprot |
P31749
|
| Calculated MW |
56kDa
|
| Cellular Localization |
Cytoplasm. Nucleus. Cell membrane. Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus.
|
| Concentration |
0.7 mg/mL
|
| Storage |
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
|
| Buffer |
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
|
| Purification Method |
Affinity purification
|
| Research Areas |
Cancer; Epigenetics and Nuclear Signaling; Metabolism; Signal Transduction
|
| Conjugation |
Unconjugated
|
| Background |
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.
|
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