Size:50ug Protein Name: TAU pT181 Synonym: DDPAC,FTDP-17,MAPT,MSTD,MTBT1,Tau,PHF-tau,TAU Uniprot No.: P10636-8 Expression System:E. Coli Compound Identity:6xHis at C-terminus Full Length or Truncated:Full length Molecular Weight: 48.3 kDa Modification Phosphorylation Form: freeze-dried powder Storage: 2 days when stored at 2 to 8 °C after thawing Up to 12 months when aliquoted and stored at -20 to -80 °C Stability: ≤6 months Purity: ≥80% estimated by SDS-PAGE Supplied in: 0.15 M Phosphate buffered saline, pH 7.4
Background
Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimers disease, frontotemporal dementia, and other tauopathies.