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- 2025年12月05日
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货期：1-2天
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- CAS号：
50635-12-6
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1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 1 mg | 产品价格： | ￥415.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1000.0 |
| 规格： | 10 mg | 产品价格： | ￥1600.0 |
| 规格： | 25 mg | 产品价格： | ￥3200.0 |
| 规格： | 50 mg | 产品价格： | ￥4560.0 |
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Aβ42 agonist-1
CAS No. : 50635-12-6
MCE 国际站：Aβ42 agonist-1
产品活性：Aβ42 agonist-1 (compound 7a) 是能够促进 Aβ42 聚集的小分子化合物。Aβ42 agonist-1 可以与 Aβ42 寡聚体和五聚体相互作用，促进无毒聚集体自组装和快速原纤维形成。Aβ42 agonist-1 可防止 Aβ42 诱导的对 HT22 海马神经元细胞的细胞毒性。
研究领域：Neuronal Signaling
作用靶点：Amyloid-β
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文献和实验Electrophoretic Separation and Immunoblotting of Aβ1–40and Aβ1–42
encoding presenilin 1 and presenilin 2. They were shown to alter APP metabolism and, in particular, to either increase total Aβ or the relative abundance of the longer Aβ42 isoform (12 -17 ). These observations have led to the hypothesis that Aβ42
Quantifying Aβ1–40 and Aβ1–42 Using Sandwich-ELISA
with autosomal penetrance (reviewed in ref . 1 ). Several of these FAD-associated APP mutations, as well as FAD-associated mutations in the presenilin 1 (PS1) and presenilin 2 (PS2) genes, lead to an increase in the production of Aβ1 –42 relative to Aβ1 _40
at amino acid Ala-42. Due to the tendency of the longer Aβ peptides to more readily form fibrils (7 ), these may accelerate Aβ deposition, which ultimately leads to more aggressive, early onset forms of Alzheimer’s disease (8 ). With the transgenic
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