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T-98475
CAS No. : 199119-18-1
MCE 国际站：T-98475
产品活性：T-98475 (Compound 26d) 是一种有效的、具有口服活性的、非肽类 luteinizing hormone-releasing hormone (LHRH) receptor 拮抗剂，IC50 值为 0.2 nM。
研究领域：Others
作用靶点：Others
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文献和实验Polymerase Chain Reaction for Detection of the t(14;18) Translocation in Lymphomas
The t(14;18) (q21;q32) translocation was originally identified as occurring in follicular low-grade non-Hodgkin’s lymphomas of B-cell origin in 1978 (1), and has been found in up to 85% of cases subsequently (2 –4 ). The translocation
Simultaneous Quantification of t(14;18) and HPRT Exon 2/3 Deletions in Human Lymphocytes
measures the frequency of t(14;18) translocations that result in the dysfunctional regulation of the antiapoptotic gene BCL-2 . The other assay measures the frequency of a deletion caused by illegitimate V(D)J recombination in the X-linked HPRT gene.
Molecular Detection of t(14;18)(q32;q21) in Follicular Lymphoma
The t(14;18)(q32;q21) can be detected in approximately 80% of cases of follicular lymphoma (FL). This translocation juxtaposes the BCL2 oncogene at 18q21 with the IGH@ at 14q32, and leads to overexpression of BCL2 protein which protects
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