SHMT-IN-2,2102681-49-0

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SHMT-IN-2

CAS No. : 2102681-49-0

MCE 国际站：SHMT-IN-2

产品活性：SHMT-IN-2 是一种特异性人SHMT1/2 抑制剂，对 SHMT1 和 SHMT2 的 IC₅₀ 值分别为 13 nM 和 66 nM。SHMT-IN-2 可以抑制许多人类癌细胞的生长，对 B 细胞淋巴瘤有敏感性。

研究领域：Others

作用靶点：Others

In Vitro: SHMT-IN-2 (compound 2) can inhibit cell growth with cellular IC₅₀ values of 2800 nM and 36 nM for SHMT1 and SHMT2, respectively.
SHMT-IN-2 (30 μM) shows the growth sensitivity with the median IC₅₀ was 4 μM to a panel of nearly 300 human cancer cell lines (with IC₅₀ values of 1.72 μM and 1.73 μM for CCRF-CEM and HT,respectively), cell lines of B-cell lymphoma origin were enriched in the more sensitive half of cells.

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