Drotrecogin alfa (activated)

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Drotrecogin alfa (activated)

CAS No. : 98530-76-8

MCE 国际站：Drotrecogin alfa (activated)

产品活性：Drotrecogin alfa activated (DrotAA) 是重组人活化蛋白C (APC)。Drotrecogin alfa activated 抑制烟雾诱导的大鼠肺微血管通透性和促炎细胞因子 IL-1β 的增加。Drotrecogin alfa activated 抑制凝血和炎症，促进纤溶。Drotrecogin alfa activated 可用于重症脓毒症的研究。

研究领域：Others

作用靶点：Others

In Vivo: Drotrecogin alfa activated (0-20 mg/kg, IV immediately following smoke exposure, once) significantly attenuates smoke inhalation injury in a dose-dependent manner at 2 hours after insult. Drotrecogin alfa activated (20 mg/kg) has an improvement of the expiration phase of pulmonary dynamic compliance.

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