IBS008738,385425-03-6

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IBS008738

CAS No. : 385425-03-6

MCE 国际站：IBS008738

产品活性：IBS008738 是一种有效的 TAZ 激活剂。IBS008738 稳定C2C12 细胞中的 TAZ，增加未磷酸化的 TAZ 水平，增强 MyoD 与肌细胞生成素启动子的结合，上调 MyoD 依赖性基因转录，并与肌肉生长抑制素竞争。IBS008738 增强 C2C12 细胞的肌生成并促进肌肉损伤模型中的肌肉修复。

研究领域：Others

作用靶点：Others

In Vitro: IBS008738 (0, 24, 48, 72 h) enhances TAZ expression, with a peak at 24 h.
?IBS008738 (10 μM; 0, 24, 72 h) enhances mRNAs of myogenic markers but not of myofusion markers.
?IBS008738 (10 μM; 24h) enhances mRNAs of IL-10 in C2C12 cells.

In Vivo: IBS008738 (3 nmol) facilitates muscle repair in Cardiotoxin-injected muscles.
?IBS008738 (30 μM, 100 μL) prevents Dexamethasone (HY-14648)-induced muscle atrophy.
?IBS008738 (100-μL volume of 30 μM; intramuscular injection; immediately and on day 2 after TBI) diminishes the expression of TNF α and IL-6 but increases that of IL-10 mRNAs in muscles of traumatic brain injury (TBI).

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