4′-Bromoflavone4-溴黄酮,20525-20-

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4′-Bromoflavone

CAS No. : 20525-20-6

MCE 国际站：4′-Bromoflavone

产品活性：4′-Bromoflavone 是一种癌症化学预防剂，是一种有效的 II 期解毒酶诱导剂。

研究领域：Others

作用靶点：Others

In Vitro: 4′-Bromoflavone significantly induces quinone reductase (QR) activity in cultured murine hepatoma 1c1c7 cells (concentration to double activity: 10 nM) and effectively induces the α- and mu-isoforms of glutathione S-transferase in cultured H4IIE rat hepatoma cells with no observed toxicity.
4′-Bromoflavone is a potent inhibitor of cytochrome P4501A1-mediated ethoxyresorufin-O-deethylase activity, with an IC₅₀ of 0.86 μM. In HepG2 or MCF-7 cells, 4′-Bromoflavone significantly reduces the covalent binding of metabolically activated benzo[a]pyrene to cellular DNA.

In Vivo: In short-term dietary studies, 4′-Bromoflavone is also shown to increase QR activity and glutathione levels in rat liver, mammary gland, colon, stomach, and lung in a dose-dependent manner. In studies conducted with female Sprague Dawley rats ,4′-Bromoflavone significantly increases QR activity (phase II enzyme).

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